Our research focuses on the etiological risk factors of addiction and how to best clinically intervene in the presence of such risk factors. Our past research has focused on how certain personality traits, trauma experiences and neurobiological risk factors can increase vulnerability to alcohol and other substances. Specific to cannabis use, we have conducted recent research that identifies different groups of cannabis users and illustrate the patterns of use that are suggestive of difficulties warranting clinical intervention. Overall, our research highlights that not all substance users are the same in terms of their risk of experiencing substance-related problems and that interventions should be matched to the user’s specific risk profile.